Metabolic Response of Slowly Absorbed Carbohydrates in Type 2 Diabetes Mellitus by Meidjie Ang

Author:Meidjie Ang
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

In this model, insulin is assumed to act from a compartment remote from plasma (Sherwin et al. 1974; Insel et al. 1975; Zeleznik and Roth 1978). This compartment could be bound insulin, insulin mediator, and/or the intracellular metabolic effects of insulin. Plasma insulin first enters the remote active insulin compartment with the rate parameter k 2, and acts to accelerate peripheral glucose disposal and inhibit net hepatic glucose production. This action, represented by the respective rate parameters k 4 and k 6, is proportional to insulin concentration in the remote compartment. The degradation rate of remote active insulin is represented as k 3, which might be related to recycling of insulin receptor, insulin mediator, and insulin induced metabolic enzymes (Bergman et al. 1979, 1985).

The minimal model can be described in 2 equations

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